I'm in the process of retrofitting an old 3.5" floppy duplicator, to enable bulk imaging of disks. The unit I'm working on is conveniently designed around a main system board and a separate board controlling the mechanisms, connected via an RS-232 serial link. That means I can easily replace the main system board with a kryoflux and a USB->RS232 adapter cable.
Right now, my current plan is to hang both the kryoflux and the serial adapter off a hub connected to a PC running linux. If there was ARM-Linux support, I'd be tempted to build a raspberry pi (or other embedded ARM linux board) into the enclosure instead.